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UNC8153 TFA

CAS No. 2929304-61-8

UNC8153 TFA( —— )

Catalog No. M37355 CAS No. 2929304-61-8

UNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UNC8153 TFA
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.
  • Description
    UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Methyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2929304-61-8
  • Formula Weight
    697.7
  • Molecular Formula
    C35H38F3N5O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C(F)(F)F.O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188. ?
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